LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
نویسندگان
چکیده
منابع مشابه
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based comparative genomic hybridization analysis with 14 MM cell lines. Three cell lines showed overlapping homozygous deletion at chromosome 13q12, which harbored the LATS2 (large tumor suppressor homolog 2) gene. With 6 other MM cell lines and 25 MM tumors, we found 10 ina...
متن کاملMolecular and Cellular Pathobiology LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based comparative genomic hybridization analysis with 14 MM cell lines. Three cell lines showed overlapping homozygous deletion at chromosome 13q12, which harbored the LATS2 (large tumor suppressor homolog 2) gene. With 6 otherMM cell lines and 25MM tumors, we found 10 inact...
متن کاملStability of the LATS2 tumor suppressor gene is regulated by tristetraprolin.
LATS2 is a tumor suppressor gene implicated in the control of cell growth and the cell cycle. Here, we investigated the post-transcriptional regulation of LATS2 expression by tristetraprolin (TTP). Our results show that the expression level of LATS2 is inversely correlated with TTP expression in human cancer cell lines. Overexpression of TTP reduced the expression level of LATS2. Conversely, tr...
متن کاملmiR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is an asbestos-induced cancer with poor prognosis that displays characteristic alterations in microRNA expression. Recently it was reported that the expression of a subset of microRNAs can distinguish between MPM and adenocarcinoma of the lung. However, the functional importance of these changes has yet to be investigated. We compared expression of miR-192, ...
متن کاملTumor suppressor gene alterations in patients with malignant mesothelioma due to environmental asbestos exposure in Turkey
BACKGROUND Environmental asbestos exposure can cause the grave lung and pleura malignancies with a high mortality rate, and it is also associated with increased rate of other organ malignancies. Asbestos exposure can develop genotoxic effects and damage in the pleura and lungs. OBJECTIVE In this study, we aimed to determine tumor suppressor gene (TSG) loss in genomic DNA which was isolated fr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2011
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-10-2164